Summary of Lost Connections

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Lost Connections book summary

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  • Controversial
  • Eye Opening
  • Concrete Examples


After taking his first antidepressant at age 18, journalist Johann Hari wanted to know why he – and millions like him – still experienced depression despite medication and therapy. He spent three years traveling some 40,000 miles to interview more than 200 people about depression and anxiety. He found that depression can result from traumatic experiences, a toxic environment or chemical imbalances in the brain. Hari reports on the challenges of the traditional biological model of depression and offers meaningful strategies to help sufferers reconnect with the status and respect they require to give their lives meaning. 

About the Author

​​Journalist Johann Hari wrote the New York Times bestseller Chasing the Scream. He has written for The New York Times, The Los Angeles Times and other publications.


Biology, environment or a combination of both can cause mental depression, which is more complicated than having bad brain chemistry.

Prescription antidepressants became mainstream in the 1990s, but their use started as early as 1952 when doctors noticed that a tuberculosis drug made patients suddenly feel euphoric. By the 1970s, doctors thought low levels of serotonin might cause depression, a theory that persists. The mainstream scientific community identified two kinds of depression: “endogenous” and “reactive.” Some type of malfunction of the brain or body causes endogenous depression. A person’s environment or personal experience can cause “reactive depression.”

In the 1970s, anthropologist George Brown and therapist and researcher Tirril Harris interviewed women in Camberwell, a working-class area of South London. While 114 of these women had a diagnosis of depression, 344 women from the same area didn’t. Brown and Harris studied both groups for a year. They interviewed the women multiple times, asking if they had experienced severe losses or negative events in the year before they became depressed. The researchers labeled negative events as “difficulties” and...

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